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2007 The irbesartan in heart failure with preserved systolic function I-PRESERVE trial: rationale and design. Plasma protein binding is approximately 96, the average volume of distribution is 53 93 liters. Also, low doses of diuretic such as hydrochlorothiazide may be added to improve therapeutic effect. The dosage can be increased after to weeks of therapy to maximum of one 300 25 mg tablet once daily as needed to control jixtru irbesartan minghajr tabib blood pressure see Clinical Studies. Mg, or 25 mg produced further dose-related reductions in blood pressure similar to those achieved with the same monotherapy dose of irbesartan. The secondary objectives are: to compare the reduction of mean Seated Systolic Blood Pressure SeSBP at the end of weeks from baseline between each FDC, its individual constituents administered as monotherapy and placebo.

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